Modulation of the IL-33/IL-13 Axis in Obesity by IL-13Rα2

TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.

IL-13 signaling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis

BACKGROUND Allograft fibrosis still remains a critical problem in transplantation, including heart transplantation. The IL-13/TGF-β1 interaction has previously been identified as a key pathway orchestrating fibrosis in different inflammatory immune disorders. Here we investigate if this pathway is also responsible for allograft fibrosis and if interference with the IL-13/TGF-β1 interaction prev...

Cytoplasmic tail of IL-13Rα2 regulates IL-4 signal transduction

IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Rα1 (IL-13 receptor α-chain 1) and IL-4Rα. The second IL-13R (IL-13 receptor) has been identified, namely IL-13Rα2. This has been thought to be a decoy receptor due to it...

The Modulation of Pulmonary Fibrosis by IL - 13 Rα 2

24 Pulmonary Fibrosis is a progressive and fatal disease that involves the remodelling of the 25 distal airspace and the lung parenchyma which results in compromised gas exchange. The 26 median survival time once diagnosed is less than 3 yrs. IL-13 has been shown to play a role 27 in a number of inflammatory and fibrotic diseases. IL-13 modulates its effector functions via 28 a complex receptor...

The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology

Human tuberculosis (TB) is a leading global health threat and still constitutes a major medical challenge. However, mechanisms governing tissue pathology during post-primary TB remain elusive, partly because genetically or immunologically tractable animal models are lacking. In human TB, the demonstration of a large relative increase in interleukin (IL)-4 and IL-13 expression, which correlates ...